Health Officials Name a Likely Culprit in Lung Disease Outbreak

State and federal investigators have discovered that many of the illegal THC oil cartridges provided for testing by the victims of a mysterious lung condition contain a thick cutting agent called tocopherol acetate, or more commonly vitamin E acetate. New York State authorities are calling the substance a “key focus” of their investigation.

The story was first reported by the Washington Post, which referred to the substance as an oil. It technically isn’t an oil (though it is oil soluble), but can cause serious lung damage anyway. The possibility that tocopherol acetate could be responsible for the lung injuries was first raised by Leafly’s David Downs in an article published Aug. 30.

Tocopherol acetate is commonly used in skin creams, soaps, and other cosmetic products, but is not intended for inhalation. However, according to Leafly, it appears to be a primary ingredient in a thick diluent called Honey Cut that is popular with makers of black market hash oil. Honey Cut is mixed with the oil extracted from cannabis flower to dilute the product so more cartridges can be filled (and sold illegally).

The Honey Cut website, which has no address or contact information, was down Thursday evening.

The Post says the information was shared by federal investigators earlier this week in a phone briefing held with state officials, and the results aligned with testing done earlier by New York State health officials.

“We knew from earlier testing by New York that they had found vitamin E acetate, but to have FDA talk about it from their overall testing plan, that was the most remarkable thing that we heard,” an unnamed state official told the Post.

“At least one vitamin E acetate containing vape product has been linked to each patient who submitted a product for testing,” said a New York State Department of Health update issued Thursday. New York says that “vitamin E acetate is now a key focus of the Department's investigation of potential causes of vaping-associated pulmonary illnesses.” The state is currently investigating 34 cases.

"Our data are starting to agree with other sources of data that most of the products are non-traditional ... products," Acting FDA Commissioner Ned Sharpless told POLITICO. "It’s still too early to say definitively what is happening, but we’re very concerned."

One scientist from the University of Rochester (New York) told POLITICO that vitamin E acetate couldn’t have caused the lipoid pneumonia in patients he examined, since the substance is not an oil. Bryn Mawr College chemistry professor Michelle Francl told the Post that vitamin E acetate is “basically grease.” When it is heated and vaporized, it can decompose. And “now you’re breathing in who-knows-what,” she said. Then when it cools in the lungs, it returns to its original state and “it has now coated the inside of your lungs with that oil.”

Lipoid pneumonia aside, it is possible that the lung damage outbreak has multiple root causes. Some of the cases may have been caused by other kinds of contamination—fungicides or pesticides, for example. In a series of tweets Thursday, Dr. Konstantinos Farsalinos suggested we withhold judgement for now.

More than 200 cases are being investigated nationwide, and two people have died—one in Illinois and one in Oregon. The Oregon victim appears to have used a cannabis oil vape purchased from a dispensary, which seems to be the first time legal products have been involved.