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Best CBD Oil 2021
Last updated: March 12, 2021

Best CBD Oil for Anxiety 2021

The strongest and most effective CBD oils for anxiety from the top brands in the industry.
1st Place
CBDistillery Extra Strength
CBDistillery Extra Strength

CBDistillery Extra Strength tincture provides 5000 mg of full spectrum cannabidiol per 30 mL bottle. It’s the strongest CBD oil you can get right now for the best value.

R+R Medicinals CBD Oil
R+R Medicinals CBD Oil
Hemp Bombs CBD Oil
hemp bombs cbd tincture watermelon

CBD oil for anxiety

CBD oil, or cannabidiol oil, is a tincture derived from hemp that is formulated for sublingual (under the tongue) use. CBD, the non-psychoactive component of cannabis, has shown promise in treating a long list of symptoms associated with anxiety and depression according to multiple scientific studies and surveys—and thousands of personal anecdotes from long-term CBD users. Using CBD oil tinctures sublingually is one of the easiest, fastest, and most effective ways to take CBD.

But what are the best high-strength CBD oil tinctures for anxiety? There are so many to choose from! While it’s impossible to try every product on the market, it’s also not necessary. There are accepted industry standards that all must be met for us to even consider the products. The best CBD products, which you will find in this list, come with batch traceability, credible third-party lab testing, properly labeled cannabinoid content, and THC concentrations within the legal limits.

Remember that the CBD oil tinctures on this page are designed for sublingual use only. They are not to be confused with CBD vapes, which are specifically made for direct inhalation. Keep reading to learn more about how CBD oil can help with your anxiety.

Please do not attempt to vape these oils. They're made specifically for oral use.

CBDistillery Extra Strength

CBDistillery Extra Strength

This is the strongest CBD oil you can get for the best value. CBDistillery Extra Strength tincture provides 5000 mg of full spectrum cannabidiol per 30 mL bottle. It is extracted from non-GMO hemp, grown with natural farming practices. It’s formulated in an ISO-certified lab and is third-party lab certified.

R+R Medicinals CBD Oil

R+R Medicinals CBD Oil

R + R Medicinals utilizes organic hemp grown in Colorado, USA. Their full spectrum CBD oil tinctures are made using CO2 extraction, which preserves the natural phytonutrients of the plant. They come in peppermint and unflavored, and are available in 500, 1000 and 2500 mg CBD strengths.

hemp bombs cbd tincture watermelon

Hemp Bombs CBD Oil

Hemp Bombs CBD oil contains premium CBD isolate extracted from European hemp. By using CBD isolate instead of a whole-plant extraction method, they’re able to achieve better flavor. Hemp Bombs is available in some of the highest strengths available containing up to 4,000 mg CBD and comes in watermelon and peppermint.

Nanocraft CBD Gold Series

NanoCraft Gold Series

NanoCraft Gold Series is a potent blend of organic broad spectrum CBD. It is packed with a wide range of cannabinoids, terpenes and nutrients, minus the THC. It contains 3000 mg of CBD that goes through a special chromatographic purification process. Each batch is third-party tested to ensure quality and consistency.


Charlotte’s Web Hemp Extract

Charlotte’s Web offers the most premium full spectrum hemp extract you can get. This tincture comes in 30 mL and 60 mL sizes containing 300-600 mg CBD, or 60 mg per mL. It also contains the entire spectrum of phytocannabinoids and terpenes extracted from USA-grown organic hemp. It’s available in three flavors.

How to use CBD oil for anxiety

The best way to administer CBD oil tinctures for anxiety is to take a hearty dose (at least 20 mg) twice a day, in the morning and before bedtime. This can help to reduce your anxiety symptoms–before they start. You might also want to take an additional dose prior to an event that you suspect might trigger your symptoms.

Even if you don’t suffer from severe anxiety, everyone experiences anxiety at some point in their life. It’s part of being human. Imagine you have to make a speech in front of a large crowd of people tomorrow, or you have that big job interview, or a work presentation tomorrow morning. CBD could potentially help you keep your anxiety under control if taken proactively on a regular basis.

CBD edibles and capsules are a great way to obtain higher dosages throughout the day, but are less efficient delivery systems compared to oil tinctures. CBD vapes and e-liquids happen to be the fastest and most effective delivery method. CBD transdermal patches are another discreet option that falls somewhere in between oil tinctures and edibles, in terms of their effectiveness.

how to take cbd oil infographic

Tips for using CBD oil for anxiety

  • Make sure your CBD oil is from a trusted source and has been properly lab tested. Look at the COA (Certificate of Analysis) of your product.
  • Make sure that the bottle is fully sealed and then shake it well.
  • Open the bottle and remove the glass dropper. Squeeze the excess air out of it.
  • Dip the dropper into the bottle and squeeze the rubber bulb to extract your preferred dosage (typically around 1 mL, or about 20 drops).
  • Drop the oil directly under your tongue and hold it for 30-60 seconds before swallowing, to allow time for it to absorb into your system.
  • The effects may take 10-30 minutes to kick in, or up to an hour when taken orally.
  • Stick to a consistent daily regimen of twice a day, morning and night.
  • Take an extra dose prior to stressful situations that can trigger anxiety.
  • If you are not getting the results you were looking for, gradually increase your dosage or try a broad-spectrum or full-spectrum CBD oil.

How much CBD oil do I take for anxiety?

Anxiety requires some of the highest dosages of CBD, compared to other conditions. Your ideal CBD dosage is going to be dependent on a plethora of factors including body type, severity of condition, and the potency and effectiveness of your CBD oil. The average recommended dosage for anxiety is approximately 40 mg per day, but can go up to 300 mg (or more) in some cases.

The best approach is to start low, and gradually work your way up (by 5 mg at a time) until you get the results you want, then stick with it. Premium CBD oil is not cheap, so using more than necessary is just a waste of money. To learn how to find the right CBD dosage for you, see our full guide.

There are a few other variables to consider besides CBD strength. CBD oil comes in three main varieties, including full-spectrum, broad-spectrum and isolate. The term isolate refers to a THC-free CBD oil made with an isolated form of CBD that doesn’t contain any additional compounds from the hemp plant.

Full-spectrum and broad-spectrum CBD oils, on the other hand, contain CBD plus other organic compounds which includes a variety of cannabinoids and terpenes. These compounds interact with CBD to produce what is known as the entourage effect, making them potentially more effective than isolated CBD, even at lower dosages. This is an important factor to take into account, especially if you are not getting favorable results with your current CBD oil for reducing anxiety.

Does CBD oil help with depression?

There is still not a lot of definitive research on whether CBD oil can be used to treat depression. However, a 2020 Austrian case study has shown potential for CBD as an alternative option to antidepressants: “in this case, CBD was a safe and well-tolerated medication for a patient with multiple substance abuse, social phobia, depression and a comorbid personality disorder. Upon treatment with CBD and cessation of the antidepressant medication, the patient improved regarding depressive as well as anxiety symptoms…”. It is important to note that this was from one isolated case study. Always speak to your doctor first before implementing CBD into your regimen, especially if you are currently prescribed to any medication.

In a 2018 Brazilian study, rodents were given 30 mg/kg CBD oil over the course of two weeks. A reduction in depression and general anxiety was observed. A 2020 study has revealed the antidepressant-like effects of β-caryophyllene, a terpene found in most hemp and cannabis plants, including popular strains like OG Kush and Sour Diesel. There is still a lot more long-term research that needs to be conducted with larger sample groups, but the current data indicates that CBD oil can provide relief for depression, especially the full and broad-spectrum varieties.

How long does CBD oil take to work?

Sublingual delivery of CBD oil can take about 10-30 minutes to take effect, and up to an hour when taken orally. CBD oral tinctures are easily one of the best ways to take CBD, but the effects are not instantaneous. It is also important to note that treating anxiety calls for some of the highest doses of CBD compared to other conditions, so if you’re not taking at least 40 mg or more on a daily basis, you might not notice any effects until increasing your dosage to meet your needs.

You may also want to consider trying a broad or full-spectrum CBD oil before switching to a higher dosage. If you are looking for the fastest possible results, vaping CBD is going to be your best option, especially if you already vape. Other methods of delivery can take up to an hour whereas vaping it is instantaneous.

Does CBD cause anxiety?

No. Cannabidiol has been shown to have the opposite effect, due to its anxiolytic properties. Anxiety and paranoia are common symptoms associated with THC. CBD can actually balance out these effects and reduce anxiety, even when it is caused by THC. Not only does CBD not cause anxiety; but it actually prevents it.

Most CBD oil tinctures are extremely low in THC—the legal limit is less than 0.3%. Unless you get it from a legal cannabis dispensary, it’s not going to have much more than that. Even if it contains a slightly higher level of THC than 0.3%, the THC will most likely be counteracted by the higher cannabidiol content. There have been studies conducted which support this cannabinoid interaction between specifically CBD and THC.

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