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Best CBD Oil 2021
Last updated: June 2, 2021

Best CBD for Pain 2021

The best CBD oils and creams for natural and effective pain management
1st Place
CBDfx CBD Oil Tincture
CBDfx CBD Oil Tincture

CBDfx offers their highest strength CBD oil yet. It’s formulated with MCT oil and CBD derived from hemp using CO2 extraction. Available in 500 to 1500 mg CBD strengths.

R+R Medicinals CBD Oil
R+R Medicinals CBD Oil
Charlotte’s Web Hemp Extract

CBD tinctures

One of the many benefits associated with CBD oil is its use for pain management. The best way to take CBD products (aside from CBD vapes) is the sublingual use of oral tinctures. CBD topicals are also a great option for more localized treatment. They are generally formulated with ingredients that are good for your skin and contain natural healing properties, like coconut oil, shea butter and peppermint. CBD creams are most effective when used in conjunction with some of the best CBD oil tinctures.

In this guide, we take a look at the best hemp-based CBD tinctures and creams for pain from the top brands right now. All of them are put through extensive lab testing, and have been carefully selected based on research and experience.

CBDfx CBD Oil Tincture

CBDfx CBD Oil Tincture

CBDfx has recently introduced their highest concentrated CBD oil line thus far. It’s formulated with MCT oil derived from coconuts and is now also available in a few exciting flavor varieties. They start at 500 mg and go up to 1,500 mg CBD. CBDfx employs a supercritical CO2 extraction process using organic industrial hemp.

R+R Medicinals CBD Oil

R+R Medicinals CBD Oil

R+R Medicinals provides premium products made from USDA organic hemp. They use CO2 extraction and all of their products go through extensive lab testing. Enjoy a full serving of flavonoids, antioxidants, and phytonutrients. They’re available in 30 mL bottles containing 500-2500 mg, and in fresh mint and natural.


Charlotte’s Web Hemp Extract

Charlotte’s Web offers the most premium full spectrum hemp extract you can get. This tincture comes in 30 mL and 60 mL sizes containing 300-600 mg CBD, or 60 mg per mL. It also contains the entire spectrum of phytocannabinoids and terpenes extracted from USA-grown hemp. It’s now available in three flavors.

Avida Full Spectrum

Avida Full Spectrum

Avida offers a full spectrum MCT oil tincture in 125 mg or 500 mg strengths. Their oil contains less than 0.3% THC and features CORE Spectrum technology. They use a proprietary blend of phytocannabinoids, terpenes and natural spearmint extract. Their CBD tinctures are BPA free, gluten-free and third-party lab tested.

CBD topical

CBDfx Hemp Cream

CBDfx Hemp Cream

CBDfx now offers a hemp-based CBD pain cream. It isn’t greasy and it has a fresh peppermint scent. Each 50 mL bottle contains 150 mg of active CBD and organic ingredients like caffeine and white willow bark. It also has naturally-extracted menthol derived from real peppermint that leaves a fresh cooling sensation.

hemp bombs cbd pain freeze

Hemp Bombs Pain Rub

Hemp Bombs Pain Rub is a triple-medicating bio-coolant that promotes relief for joint and arthritis pain, muscle aches, back and knee pain. It contains active ingredients like menthol for a full cold therapy profile. It comes in 1 oz and 4 oz containing 50 or 200 mg of CBD. Try Hemp Bombs Pain Rub for a natural choice.

JustCBD Pain Roll On

JustCBD Pain Roll On

JustCBD Pain Roll On cream provides a very convenient way to apply CBD for pain. It contains a variety of essential oils and is formulated with 350 mg CBD in total. It is designed for pain relief and has a menthol scent profile. JustCBD is one of the top brands for CBD, and their Pain Roll On is just what you need.

Green Roads Pain Relief Cream

Green Roads Pain Relief Cream

Green Roads offers a specially formulated topical for pain. It comes in a pharmaceutical-grade cream base and can be applied every 4 to 6 hours. It provides a calming and effective delivery system for pain treatment. It also contains fresh and soothing menthol. Green Roads Pain Relief comes in 60 mL bottles containing 300 mg of CBD oil.

CBD oil for pain

Pain is a real thing! It’s also a complex issue. Some pain is chronic, while others suffer from less severe pain, but nonetheless nagging discomfort that adds to stress levels and anxiety. And for those with lower levels, the diagnosis may not qualify for prescription pain medication. Whether you’re dealing with back pain, arthritis of generalized joint pain, or from fibromyalgia, pain is a reality for a huge population of the planet. No matter the cause, no one gets through life without experiencing it. And everyone that goes through it deserves relief.

But does CBD oil work for pain? There have been a plethora of studies on CBD and pain, but most were conducted on animals. While that’s great for our furry friends, and CBD for dogs has become almost an industry on its own, human-based clinical research is not as robust. Multiple studies that have been conducted on humans, like one in Uraguay in 2018, the UK in 2003 and Italy in 2007 have shown a positive correlation with pain relief in humans, with little to no adverse effects, or some side effects that are well tolerated.

According to a research study conducted from 2017 to 2018 examining the increasing popularity of CBD usage, the results showed that over 62% of the users were self-treating for a medical condition; utilizing CBD oil for anxiety, depression and pain. And more than 1/3 of those individuals reported that CBD worked “very well by itself.”

CBD oil vs. opioids

Prescription opioids for pain management have wreaked havoc on our society, while pharmaceutical companies raked in the profits. People suffering from chronic and debilitating pain need help, which is a major contributing factor in the tragedy of the opioid abuse crisis. There’s always someone in need of relief, and the prescription drug industry is quick to pass out pills, regardless of the risks. And make no mistake about it, opioids in any form taken for any reason are a huge risk!

It’s impossible to take opioids for pain and avoid serious risks to your health. As stated on CDC.gov, “…Opioids pose a risk to all patients. Anyone taking prescription opioids is at risk for unintentional overdose or death and can become addicted. From 1999 to 2017, more than 218,000 people died from overdose related to prescription opioids in the United States. Up to 1 out of 4 people receiving long-term opioid therapy in a primary care setting struggles with opioid use disorder.”

In a 2008 study published in Pain Physicians Journal, they examined the side effects of opioids, “Common side effects of opioid administration include sedation, dizziness, nausea, vomiting, constipation, physical dependence, tolerance, and respiratory depression.” In comparison, studies have shown few side effects attributed to CBD, especially compared to opioids and other over-the-counter and prescription pain medication.

Benefits and side effects from CBD oil

Health Benefits of Cannabidiol-Infographic

There is still a lot more research that needs to be done but in a 2017 study published in Cannabis & Cannabinoid Research, “the most commonly reported side effects of CBD were tiredness, diarrhea, and changes of appetite/weight. In comparison with other drugs, used for the treatment of these medical conditions, CBD has a better side effect profile.”

There has been scientific research suggesting that CBD can provide potential benefits for a long list of conditions. The more well-researched use of cannabidiol include seizures, anxiety, sleep disorders and pain management. There are other studies that suggest CBD could have additional benefits for psychosis, heart disease, diabetes and reducing inflammation, but more human case studies need to be conducted with much larger sample sizes. The most common reasons for taking CBD, based on a 2018 study of 2,400 CBD users were chronic pain, arthritis joint pain and anxiety.

Pain ailments associated with relief from CBD

Based on medical surveys taken from CBD users, some of the most well-documented pain-related issues that people take CBD are for:

  • Chronic pain
  • Arthritis joint pain
  • Back pain
  • Multiple sclerosis
  • Joint pain
  • Post-workout relief

A 2017 publication from the National Academies Press reports “Relief from chronic pain is by far the most common condition cited by patients for the medical use of cannabis. In addition, there is evidence that some individuals are replacing the use of conventional pain medications (e.g., opiates) with cannabis.

For example, one recent study reported survey data from patrons of a Michigan medical marijuana dispensary suggesting that medical cannabis use in pain patients was associated with a 64 percent reduction in opioid use.”

Personal anecdotes and surveys are among the most abundant evidence for the effectiveness of CBD in the management of pain. More clinical studies are still needed to help support these claims.

How long does CBD oil take to relieve pain?

How long it takes CBD to have an effect on you depends on a number of factors. For instance, if you’ve ever spoken to someone that said CBD didn’t work, unless they told you the dose, and delivery method, there’s no way to tell if what they tried should have even delivered any relief at all.

Also, what kind of CBD oil were they using? Was it isolate-based, broad spectrum or full spectrum? For example, a 2018 study indicates that CBD-rich whole plant hemp extracts might be more effective for treating certain conditions because they contain a wider range of phytocannabinoids and terpenes which occur naturally in cannabis/hemp plants. They are said work to synergistically, creating what is known as the entourage effect.

How to use CBD for pain

Sublingual administration of CBD takes effect sooner than edibles because they are a more direct delivery method with a much higher bioavailability. It can take anywhere from 10-30 minutes to kick in. Edibles and capsules are another popular way to administer CBD, but they can take up to twice as long to actually notice the effects.

Topical application of CBD might take longer to penetrate the skin, but has been shown to help with pain relief according to a 2016 study on rats. Transdermal administration of CBD caused a reduction in pain-related behaviors and inflammation. However, if you are using CBD topically, you may also want to supplement it with an oral tincture, capsule or vape. Topicals tend to have a lower bioavailability than the other methods of delivery including CBD patches, oils and vapes.

Vaping is by far the fastest and most effective delivery system for CBD. Keep in mind that CBD oil tinctures are not designed for vaping! They’re oil-based and not safe for inhalation. There are plenty of CBD vapes and e-liquids designed for vaping. When you’re experiencing excruciating pain, timing is crucial.

In clinical trials conducted on over 670 patients, the average dosage was between 3.2 and 22.9 mg CBD per day. Your ideal dosage might be somewhere in between, or much higher for more chronic pain conditions. There are many other variables including body weight, appetite, severity of pain, extraction method, strength etc.

The best practice is to start low and gradually increase your dosage until you achieve the relief you need. Although tinctures are slightly less bioavailable than vaping, the advantage to tinctures is that they allow you to take a high dosage of CBD within a shorter timeframe.

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